Thursday, November 16, 2017

Ginkgo; Good or Bad

I have a dozen or more Ginkgo trees, all from seed from the New York Botanical Garden trees, which were allegedly grown from seeds from the surviving Hiroshima ginkgo. The seed have just dropped and they do smell a bit rancid but after a month or two they disappear almost over night, the squirrels. Now allegedly the ginkgo increases brain capacity. So am I allowing for the evolution of brilliant squirrels?

In a recent paper by Oliveira et al they note:

Despite the ancient use in Chinese popular medicine and, more recently, in western modern medicine in many European countries, the biological effects of extracts of G. biloba (GBE) are still not clearly known. In modern medicine GBE has been used for tinnitus, to reverse memory loss, for dementia, and Alzheimer’s and Parkinson’s diseases in elderly people. Besides reports on improvement of blood circulation in the brain, there are a number of studies pointing to complex cellular effects, involving signal transduction pathways and epigenetic modifications. Evidence are presented from recent reports concerning genotoxic and antigenotoxic properties and the corresponding mechanisms underlying such activities, mostly regarding the prooxidant and antioxidant activities of the extract. However, several examples of direct interaction of the extract and its components with specific proteins are provided, especially for DNA damage repair, contributing for antigenotoxicity. Evidence of epigenetic effects of GBE are also presented from approaches involving transcriptomics, detection of activity of histone deacetylases, and screening of plant extracts with cell-based systems for detection of posttranslational modifications. The modulation of chromatin-remodeling enzymes by GBE and their interaction with proteins involved in DNA damage repair, apoptosis, and signal transduction are discussed in the context of neurodegeneration.

It is not clear what the implications are. But I have noticed my squirrels borrowing some books from my library. The works all related to editing human DNA. Should we be concerned?